A new method for isolating (E)-azastilbene derivatives with antimicrobial properties from aqueous samples

Mariusz Kluska, Ewa Witkowska-Krajewska, Wiesław Prukała

Structures of the analysed compounds: bromide of (E)-N-(o-bromobenzyl)-4’-hydroxystilbazole-4 (A1), and chloride of (E)-N-(p-chlorobenzyl)-4’-hydroxystilbazole-4 (A2)

Paper category: Original research paper
Corresponding author: Mariusz Kluska (kluskam@uph.edu.pl)
DOI: 10.1515/ohs-2018-0003
Received: 13 July 2017
Accepted: 08 September 2017
Full text: here

Abstract

This paper presents the results of a study aimed at developing the extraction process and determining long-term stability of (E)-azastilbene derivatives in order to explore their possible use as preservative, antiseptic and disinfectant substances. The study was performed in three different matrices: distilled, surface and waste water. Test substances included bromide of (E)-N-(o-bromobenzyl)-4’-hydroxystilbazole-4 and chloride of (E)-N-(p-chlorobenzyl)-4’-hydroxystilbazole-4. The extraction process involved the use of three stationary phases: octyl, octadecyl and naphthylpropyl. The highest recovery values (amounting to approx. 95%) were obtained in the naphthylpropyl column for all of the above-mentioned matrices. A decline in the stability of the analysed derivatives after a 28-day period was below 14% in all matrix types.

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Prof. UPH dr hab. at Institute of Chemistry, Siedlce University of Natural Sciences and Humanities, ul. 3 Maja 54, 08-110 Siedlce, Poland | kluskam@uph.edu.pl

Hospital Pharmacy Department, Hospital Solec Sp. z o. o., Solec 93, 00-382 Warszawa, Poland

Prof. UAM dr hab. at Faculty of Chemistry, Adam Mickiewicz University, ul. Umultowska 89b, 61-614 Poznań, Poland

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